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Curated Stack · Injectable · Ready to Use

The Renewal

Repair is expensive. Rebuilding tissue, calming inflammation, laying down new collagen — every one of those processes runs on cellular energy, and when that energy is depleted, repair slows no matter how good the signal.

The Renewal pairs KLOW's four-system repair work with NAD+ & MOTS-c, which restores the mitochondrial capacity that repair depends on. The work and the fuel to do it.

Longevity & Cellular Repair & Recovery Energy & Metabolic Injectable

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What The Renewal Does

2 Vials

Both pre-mixed and ready to use — no reconstitution

6 Peptides

BPC-157, TB-500, GHK-Cu, KPV, NAD+, and MOTS-c

Repair

Tissue, gut lining, skin, and immune regulation

Fuel

Mitochondrial function and cellular energy production

Cycled protocol

The KLOW component runs in cycles with planned breaks — your clinician sets the schedule

Important

These products are not FDA-approved and are available through licensed compounding pharmacies for use under medical supervision. This page is for educational purposes only — dosing and protocol guidance are provided by your clinician during consultation. Always work with a qualified healthcare provider before starting any injectable protocol.

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What's In The Renewal

Two vials, six peptides. One handles the repair work across four different systems. The other restores the cellular machinery that makes repair possible.

The Repair

KLOW

BPC-157 · TB-500 · GHK-Cu · KPV · pre-mixed

Four repair peptides in a single vial, each working a different pathway. BPC-157 drives structural healing in tendon, ligament, muscle, and the gut wall. TB-500 works systemically, helping cells reach injury sites. GHK-Cu activates collagen and elastin renewal for skin and connective tissue. KPV calms inflammatory signaling at the immune level. Together they cover more ground than any single peptide can.

The Fuel

NAD+ & MOTS-c

900 mg / 7.5 mg per 3 mL · pre-mixed

NAD+ is the coenzyme every cell uses to convert nutrients into usable energy, and it declines steadily with age. MOTS-c is a mitochondrial-derived peptide that improves how efficiently the mitochondria themselves operate. Paired, they address cellular energy from two directions — the raw currency and the machinery that spends it.

01

BPC-157

Structural tissue repair — tendons, ligaments, muscle, and gut lining

02

TB-500

Systemic healing and cell migration — works body-wide, not just locally

03

GHK-Cu

Collagen and elastin renewal — skin, hair, and connective tissue

04

KPV

Anti-inflammatory and immune regulation — gut lining and mast cell calming

05

NAD+

Cellular energy currency — declines with age, drives DNA repair and metabolism

06

MOTS-c

Mitochondrial efficiency and metabolic regulation

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Why These Two Together

Every repair process in the body is metabolically expensive. Synthesizing collagen, rebuilding damaged tissue, mounting and then resolving an inflammatory response, replacing the lining of the gut — all of it consumes cellular energy at a rate well above baseline.

This is why repair slows with age even when the signals are intact. NAD+ declines. Mitochondrial efficiency drops. The instructions to rebuild still arrive, but the cells receiving them have less capacity to act. The Renewal addresses both halves — KLOW supplies the repair signaling across four systems, while NAD+ and MOTS-c restore the energetic capacity to carry it out.

Repair

KLOW

Four-system repair — structural tissue, gut lining, skin and collagen, and immune regulation

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Fuel

NAD+ & MOTS-c

Cellular energy and mitochondrial function — the capacity that repair runs on

The name is the idea. Renewal isn't one thing being fixed — it's the whole system being restored to a state where it can repair itself properly again. This stack works on both what gets rebuilt and what does the rebuilding.

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What The Renewal Does For Your Body

This stack tends to work on two tracks — energy and inflammation shift relatively early, while structural and visible changes build steadily across the protocol.

Cellular Energy & Daily Stamina

NAD+ is central to how cells convert nutrients into usable energy, and levels fall considerably with age. Restoring it, alongside MOTS-c's effect on mitochondrial efficiency, tends to show up as steadier energy through the day rather than a stimulant-style lift — less afternoon flatness, more capacity for physical and mental work.

Tissue, Tendon & Joint Repair

BPC-157 and TB-500 are the most researched pairing for connective tissue healing, working particularly well in tendon and ligament where blood supply is limited and healing is normally slow. With cellular energy restored alongside them, that repair work has the metabolic capacity it needs to actually proceed.

Skin, Collagen & Visible Renewal

GHK-Cu is one of the body's most potent natural signals for collagen and elastin production. Clients typically notice improved skin firmness, softened fine lines, and more even texture across a protocol — changes that come from structural protein actually being rebuilt rather than surface treatment. Hair thickness and joint cushioning often follow with continued cycling.

Gut Lining & Digestive Comfort

BPC-157 was originally identified through gastric proteins and has a particular affinity for the gut, helping restore the mucosal lining and reduce intestinal permeability. KPV adds a second, immune-level layer of anti-inflammatory support directed at the gut wall. Improved digestive comfort is often among the earlier changes people report.

Inflammation & Immune Balance

KPV modulates NF-κB, one of the primary switches governing the body's inflammatory response. Rather than suppressing immunity broadly, it helps recalibrate an overactive response — which makes this stack relevant for chronic low-grade inflammation, mast cell activation, and post-viral recovery where immune dysregulation is part of the picture.

Metabolic & Longevity Support

MOTS-c influences how cells handle glucose and metabolic stress, while NAD+ is required by the enzymes involved in DNA repair and cellular maintenance. GHK-Cu has separately been shown to shift gene expression toward repair pathways. Together these represent the longevity-oriented layer of the stack — working on the systems that govern how well the body maintains itself over time.

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What to Expect

A general sense of how this stack tends to unfold. Individual response varies — your clinician will set expectations specific to your goals and starting point.

Early

Reduced joint discomfort and improved digestive comfort are usually the first changes noticed, as the anti-inflammatory components take effect. Energy often begins to feel steadier, though NAD+ effects can take a little longer to establish than the inflammatory ones.

Building

Daily stamina becomes more consistent and recovery from physical effort shortens. Structural repair is underway but not yet obvious. Sleep quality and mental clarity often improve during this phase as inflammation settles and cellular energy stabilizes.

Established

Visible skin changes from GHK-Cu become apparent — firmness, texture, and fine lines. Structural improvements in tendon and joint function are clearer. This is where the repair and energy halves of the stack compound most noticeably.

Ongoing

Benefits accumulate across cycles rather than plateauing within one. Your clinician will advise on cycle length, break periods, and whether to continue, adjust, or transition based on how you respond.

Dosing and scheduling are set during your consultation. Both vials are pre-mixed and ready to use, but the protocol — how much, how often, and how the two components are sequenced and cycled — is determined by your clinician based on your goals, history, and response.

This stack is cycled, not continuous. KLOW contains GHK-Cu, a copper peptide, and copper-containing protocols are run in defined cycles with planned breaks rather than taken indefinitely. Your clinician will structure that schedule as part of your protocol. Avoid additional copper supplements while using this stack unless your provider specifically directs otherwise.

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Who The Renewal Is For

/Clients who feel depleted rather than injured — where fatigue, slow recovery, and general wear are the presenting picture
/Anyone dealing with multiple overlapping issues at once — gut, joints, skin, and energy together rather than one isolated problem
/Post-viral recovery, chronic low-grade inflammation, or immune dysregulation alongside low energy
/Clients in their 40s and beyond who want a longevity-oriented protocol rather than a performance one
/Anyone who has run a repair protocol before and found results slower than expected — depleted cellular energy is often the missing piece

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Common Questions

Do these come pre-mixed, or do I have to prepare them?+

Both vials arrive as fully pre-mixed liquid, ready to draw and inject. There's no mixing or preparation required at any stage.

Why pair repair peptides with NAD+ rather than just running KLOW alone?+

Repair is metabolically demanding. Building collagen, replacing damaged tissue, and resolving inflammation all consume cellular energy well above baseline. When NAD+ is depleted and mitochondrial efficiency has dropped — both of which happen with age — repair signaling still arrives, but cells have less capacity to act on it. Adding NAD+ and MOTS-c addresses that limiting factor directly. For clients who have run repair protocols before with underwhelming results, this is frequently the piece that was missing.

How is dosing determined?+

Dosing and scheduling for both vials are set by your clinician during consultation, based on your goals, health history, and prior peptide experience. You'll receive complete written guidance covering amounts, timing, injection technique, cycle length, and break periods before you begin.

Why does this stack need to be cycled?+

KLOW contains GHK-Cu, a copper-containing peptide. Copper protocols are run in defined cycles with planned breaks rather than continuously, to avoid accumulation. Your clinician will set the specific cycle length and break period as part of your protocol. You should also avoid taking additional copper supplements during an active cycle unless your provider directs otherwise.

What's the difference between this and The Architect?+

The Architect is built around growth hormone signaling paired with tissue repair — it's oriented toward building: lean tissue development, training recovery, and body composition. The Renewal is oriented toward restoration: it addresses repair across four systems including gut and immune, and pairs that with cellular energy rather than GH. If your goal is performance and rebuilding after injury, The Architect fits better. If you feel depleted, inflamed, or generally worn down, The Renewal is the more appropriate starting point.

Can I run just one half of the stack?+

Yes — both KLOW and NAD+ & MOTS-c are available individually and work well on their own. The stack exists because they compound: repair proceeds faster when cellular energy is available to support it. If your goal is narrower — purely energy, or purely tissue repair — a single protocol may be the better place to start. Your clinician can advise.

Is this appropriate if I have an autoimmune condition?+

KPV is an immune modulator rather than a stimulant — it works by helping recalibrate an overactive inflammatory response rather than by broadly activating immunity. That said, any protocol touching immune function warrants specific clinical review if you have an autoimmune condition. Discuss your full history with your provider during consultation so they can determine whether this stack is appropriate for you.

Will I notice the NAD+ right away?+

NAD+ generally works differently from a stimulant — most people describe it as steadier baseline energy rather than a noticeable lift. Effects tend to build over a protocol rather than arriving in the first days. Some people are more sensitive to it than others, and injection timing can influence how it feels, which is something your clinician will guide you on.

How should I store these vials?+

Keep both vials refrigerated at 35–46°F (2–8°C). Do not freeze — freezing can degrade the peptides. Keep them out of direct light. Write the date you first opened each vial on its label so you can track it. If you notice cloudiness or discoloration, do not use it — contact your provider.

Where do these products come from?+

All Bespoke Biology products are sourced from USA-based licensed compounding pharmacies and are third-party tested. We're a member of the American Peptide Association. Every protocol is coordinated with clinical oversight — this is not a gray-market product and it isn't sold without a consultation.

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Side Effects to Watch For

/Injection site redness, warmth, or small bumps — rotate sites every time to reduce this
/Flushing, warmth, or a brief wave of nausea shortly after injecting — most commonly associated with the NAD+ component
/Temporary bloating or changed digestion in the first week, particularly if gut repair is active
/Mild fatigue or a groggy feeling in the first few days as the body adjusts
/Mild headache when first starting — typically resolves within a few days
/Increased thirst — stay well hydrated throughout your protocol
/Rare: a metallic taste or nausea associated with the copper component — mention this to your provider

Most effects are mild and appear only in the first week or two. Contact your provider if anything feels significant, unusual, or doesn't resolve on its own.

Ready to begin

Start With a Consultation

The Renewal is coordinated with clinical oversight. Your consultation establishes whether this stack fits your goals, and sets the protocol, dosing, and cycle schedule specific to you.

Book a Consultation