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The Recomposition

Losing weight is straightforward. Losing fat while holding onto muscle is a different problem — and the aggressive approaches that move the scale fastest are usually the ones that cost you the most lean mass.

The Recomposition pairs metabolic reset with growth hormone signaling and mitochondrial support, so the weight coming off is the weight you wanted to lose. The goal isn't a smaller version of you. It's a different composition.

Energy & Metabolic Muscle & Composition Longevity & Cellular Injectable

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What The Recomposition Does

3 Vials

All pre-mixed and ready to use — no reconstitution

5 Peptides

Retatrutide, CJC-1295, Ipamorelin, NAD+, and MOTS-c

Reduce

Appetite regulation and fat metabolism

Preserve

Lean tissue protection during a caloric deficit

Composition, not just weight

The ratio of lean mass to fat mass is the thing being changed

Important

These products are not FDA-approved and are available through licensed compounding pharmacies for use under medical supervision. This page is for educational purposes only — dosing and protocol guidance are provided by your clinician during consultation. Always work with a qualified healthcare provider before starting any injectable protocol.

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What's In The Recomposition

Three vials, five peptides. Each addresses a different part of the same problem — one drives the deficit, one protects what you don't want to lose, and one keeps the metabolic machinery running while it happens.

The Deficit

Retatrutide

A triple-receptor agonist targeting GLP-1, GIP, and glucagon pathways. It regulates appetite and satiety while influencing how the body handles glucose and mobilizes stored fat. This is the component that creates and sustains the caloric deficit — without the constant negotiation with hunger that makes deficits so difficult to hold.

The Protection

CJC-1295 & Ipamorelin

A growth hormone secretagogue pairing that restores a more youthful GH rhythm. GH signaling is central to preserving lean tissue during a deficit and to how the body partitions what it burns. Ipamorelin triggers release cleanly, without the hunger or cortisol response of older GH peptides — which matters when appetite control is the point.

The Engine

NAD+ & MOTS-c

NAD+ is the coenzyme cells use to convert nutrients into usable energy. MOTS-c is a mitochondrial-derived peptide that influences glucose handling and metabolic flexibility. In a deficit, energy production is exactly what tends to suffer — this pairing supports the metabolic machinery so the process doesn't stall out.

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Why These Three Together

A caloric deficit doesn't discriminate. When the body needs energy it doesn't have, it draws on whatever is available — and muscle is metabolically expensive tissue that the body is often willing to give up first. This is why rapid weight loss so frequently produces a smaller, softer version of the same shape, and why the metabolism that comes out the other side is slower than the one that went in.

The Recomposition is built to prevent exactly that. Retatrutide creates the deficit. Growth hormone signaling tells the body to protect lean tissue while that deficit runs. NAD+ and MOTS-c keep cellular energy production intact so the metabolism doesn't downshift in response. Three interventions on one process, each covering a failure point of the others.

Deficit

Retatrutide

Appetite regulation and fat mobilization — creates a deficit you can actually sustain

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Protection

CJC-1295 & Ipamorelin

GH signaling preserves lean tissue and shifts what the body chooses to burn

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Engine

NAD+ & MOTS-c

Cellular energy and metabolic flexibility — keeps the system from downshifting

The name is the idea. Recomposition means changing the ratio, not just the total. Two people at the same weight can have entirely different bodies — this stack is built around which of those you end up with.

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What The Recomposition Does For Your Body

Appetite and energy changes tend to arrive first. Composition changes are slower by nature — this is a stack where the scale is a poor measure of what's actually happening.

Appetite Regulation & Fat Loss

Retatrutide acts on three metabolic receptor pathways simultaneously, which affects both how full you feel and how the body handles glucose and stored fat. Most people describe the change less as suppressed appetite than as food simply occupying less mental space — the constant background negotiation quiets down, which is what makes a deficit sustainable over months rather than weeks.

Lean Mass Preservation

This is the reason the stack exists. Growth hormone signaling influences how the body partitions fuel during a deficit — protecting lean tissue and directing the shortfall toward fat stores instead. Aggressive weight loss without this protection routinely costs muscle, and muscle is what determines both how you look at a given weight and how your metabolism behaves afterward.

Energy Through the Deficit

Fatigue is the most common reason people abandon a protocol. NAD+ supports the cellular machinery that converts nutrients into usable energy, and MOTS-c influences metabolic flexibility — how readily the body switches between fuel sources. Together they address the flatness that a caloric deficit otherwise produces, which is as much a compliance benefit as a physiological one.

Deeper Sleep & Recovery

Growth hormone release is tied to slow-wave sleep, and CJC-1295 with Ipamorelin supports that architecture. Better sleep matters more during a deficit than outside one — it's when tissue repair happens, and poor sleep independently worsens appetite regulation and insulin sensitivity. This component quietly reinforces everything else in the stack.

Metabolic & Glucose Handling

Both Retatrutide's GIP and glucagon activity and MOTS-c's mitochondrial effects touch how the body manages glucose. For clients whose metabolic health is part of the goal rather than incidental to it, this stack works on the underlying handling rather than only the number on the scale.

Training Response & Adaptation

Resistance training during a deficit is the single strongest signal to preserve muscle, and this stack improves the body's ability to act on that signal. GH support aids recovery between sessions while restored cellular energy makes the sessions themselves productive. Clients who train through a Recomposition protocol consistently see better composition outcomes than those who don't.

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What to Expect

A general sense of how this stack tends to unfold. Individual response varies — your clinician will set expectations specific to your goals and starting point.

Early

Appetite changes are usually the first thing noticed — meals feel satisfying sooner and food thoughts quiet down. Some digestive adjustment is common as the body adapts. Sleep often deepens early as well.

Building

The deficit establishes and weight begins to move. Energy stabilizes rather than declining the way it typically would. Training capacity holds up better than expected for a deficit, and recovery between sessions stays intact.

Established

This is where composition changes become visible in ways the scale doesn't capture — clothes fitting differently, definition appearing, measurements changing more than weight does. Clients who track only weight often underestimate their progress at this stage.

Ongoing

Your clinician will advise on protocol duration, adjustments, and how to transition off when goals are met. Maintaining composition after a protocol is its own phase and worth planning for deliberately.

Dosing and scheduling are set during your consultation. All three vials are pre-mixed and ready to use, but the protocol — how much, how often, what time of day, and how the components are sequenced — is determined by your clinician based on your goals, history, and response.

Protein intake and resistance training are not optional here. The lean-mass protection this stack provides is a signal, not a substitute. Without adequate protein and a training stimulus telling the body that muscle is worth keeping, a deficit will still cost lean tissue. Your clinician will discuss nutritional requirements alongside the protocol.

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Who The Recomposition Is For

/Anyone who wants to lose fat without losing the muscle they've built
/Clients who have lost weight before and disliked the result — smaller but softer, with a slower metabolism than they started with
/People who train and want a protocol that supports training rather than undermining it
/Clients over 40, for whom lean mass is harder to hold and easier to lose during a deficit
/Anyone whose goal is how they look and function at a given weight, not the weight itself

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Common Questions

Do these come pre-mixed, or do I have to prepare them?+

All three vials arrive as fully pre-mixed liquid, ready to draw and inject. There's no mixing or preparation required at any stage.

Why not just use Retatrutide on its own?+

Retatrutide alone will produce weight loss, and for some goals that's sufficient. The issue is what the weight consists of. A caloric deficit without a lean-tissue protection signal draws on muscle as well as fat, which affects both how you look at your goal weight and how your metabolism functions afterward. The GH component addresses that directly, and the NAD+ and MOTS-c component prevents the energy crash that causes people to abandon protocols. The stack exists because the failure points of a single-agent approach are predictable.

How is dosing determined?+

Dosing and scheduling for all three vials are set by your clinician during consultation, based on your goals, health history, and prior experience with metabolic peptides. You'll receive complete written guidance covering amounts, timing, injection technique, and protocol duration before you begin.

Will I lose weight quickly on this?+

Weight will move, but this protocol is deliberately not optimized for maximum scale movement. Rapid loss and good composition outcomes tend to be in tension — the faster the deficit, the more lean tissue is typically sacrificed. Clients frequently find that measurements, clothing fit, and visible definition change considerably more than their weight does. If pure scale movement is the goal, tell your clinician, because a different protocol may suit you better.

Do I need to train while using this?+

Strongly recommended. Resistance training is the clearest signal you can send the body that muscle is worth preserving, and this stack improves your capacity to respond to that signal. Without it, the GH component is working against less favorable odds. Adequate protein intake matters for the same reason. Your clinician will discuss both alongside the protocol.

What happens when I stop?+

Appetite regulation from the Retatrutide component fades once it's discontinued, which is why the transition off a protocol matters as much as the protocol itself. Clients who finish with more lean mass are in a considerably better position — muscle is metabolically active tissue, so the body you end up with directly affects how well you maintain results. Your clinician will plan the transition rather than leaving it to chance.

How is this different from The Architect?+

Both include CJC-1295 & Ipamorelin, but the goals diverge from there. The Architect pairs GH signaling with tissue repair — it's oriented toward rebuilding after injury and improving recovery capacity. The Recomposition pairs GH signaling with metabolic intervention — it's oriented toward changing body composition through a managed deficit. If your priority is repair and recovery, The Architect fits better. If it's fat loss with muscle retention, this is the one.

Will this affect my natural growth hormone production?+

CJC-1295 and Ipamorelin are secretagogues — they prompt your body to release its own growth hormone rather than supplying external hormone. This preserves the natural pulsatile release pattern and the feedback loops regulating it, which is a meaningful difference from exogenous HGH. Cycling remains part of the protocol and your clinician will structure that accordingly.

How should I store these vials?+

Keep all vials refrigerated at 35–46°F (2–8°C). Do not freeze — freezing can degrade the peptides. Keep them out of direct light. Write the date you first opened each vial on its label so you can track it. If you notice cloudiness or discoloration, do not use it — contact your provider.

Where do these products come from?+

All Bespoke Biology products are sourced from USA-based licensed compounding pharmacies and are third-party tested. We're a member of the American Peptide Association. Every protocol is coordinated with clinical oversight — this is not a gray-market product and it isn't sold without a consultation.

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Side Effects to Watch For

/Nausea, particularly early in a protocol or after an increase — usually eases as the body adjusts
/Constipation, bloating, or general digestive changes as gastric emptying slows
/Reduced appetite to the point of under-eating — monitor intake, as inadequate protein undermines the entire protocol
/Mild water retention or puffiness in hands and face, associated with the GH component
/Tingling or numbness in the hands — related to fluid shifts, generally resolves with adjustment
/Injection site redness or small bumps — rotate sites every time to reduce this
/Flushing or brief nausea shortly after injecting, most often associated with the NAD+ component
/Rare: persistent vomiting or severe abdominal pain — contact your provider promptly rather than waiting

Most effects are mild and concentrated in the early phase of a protocol. Contact your provider if anything feels significant, unusual, or doesn't resolve on its own. Metabolic peptides are not appropriate for everyone — certain personal and family medical histories are contraindications your clinician will screen for.

Ready to begin

Start With a Consultation

The Recomposition is coordinated with clinical oversight. Your consultation establishes whether this stack fits your goals, and sets the protocol, dosing, and schedule specific to you.

Book a Consultation